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Roy B, Bose A, Bhaumik U, Das A, Chatterjee N, Ghosh A, Darbar S, Sarkar AK, Sengupta P, Pal TK. 2010. Convulsant activity and pharmacokinetic–pharmacodynamic modeling of the electroencephalogram effect of gemifloxacin in rats. J Pharm Sci 99:1535–1547.

✍ Scribed by Bikash Roy; Anirbandeep Bose; Uttam Bhaumik; Ayan Das; Nilendra Chatterjee; Animesh Ghosh; Soumendra Darbar; Amlan Kanti Sarkar; Pinaki Sengupta; T. K. Pal

Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 31 KB
Volume: 101
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.23012

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Retracted: Convulsant activity and pharm

Retracted: Convulsant activity and pharmacokinetic–pharmacodynamic modeling of the electroencephalogram effect of gemifloxacin in rats

✍ Bikash Roy; Anirbandeep Bose; Uttam Bhaumik; Ayan Das; Nilendra Chatterjee; Anim 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 351 KB

A pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was used to investigate the epileptogenic activity of gemifloxacin as a representative antibiotic with concentration-dependent antimicrobial activity. Rats received an intravenous infusion of gemifloxacin at a rate of 4 mg kg of body weight