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Pharmacokinetic–pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior

✍ Scribed by Marian Geldof; Jan Freijer; Ludy van Beijsterveldt; Patrick C.M. Vermote; Anton A. Megens; Meindert Danhof


Book ID
113591884
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
810 KB
Volume
32
Category
Article
ISSN
0928-0987

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Pharmacokinetic–pharmacodynamic modeling
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The prediction of chemotherapeutic efficacy is complicated by "protocol dependencies" in dose-effect and dose-toxicity relationships. It has been proposed that pharmacokinetic-pharmacodynamic mathematical models may allow characterization of chemotherapeutic protocol dependencies, and may facilitate