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Pharmacokinetic study of mucoadhesive metformin pellets in rats

✍ Scribed by Jingshu Piao, Ji-Eun Lee, Dae Hwan Shin, Jin-Seok Kim

Book ID
113112212
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
296 KB
Volume
42
Category
Article
ISSN
2093-5552

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## Abstract It was reported that metformin was mainly metabolized via hepatic CYP2C11, 2D1 and 3A1/2 in rats, and in a rat model of dehydration, the expressions of hepatic CYP2C11 and 3A1/2 were not changed. Hence, it could be expected that the __Cl__~nr~ of metformin is comparable between two grou