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Effects of Escherichia coli lipopolysaccharide on the metformin pharmacokinetics in rats

✍ Scribed by Cho, Y. K.; Choi, Y. H.; Kim, S. H.; Lee, M. G.

Book ID
121230951
Publisher
Informa plc
Year
2009
Tongue
English
Weight
796 KB
Volume
39
Category
Article
ISSN
0049-8254

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## Abstract It was reported that metformin was mainly metabolized via hepatic CYP2C11, 2D1 and 3A1/2 in rats, and in a rat model of dehydration, the expressions of hepatic CYP2C11 and 3A1/2 were not changed. Hence, it could be expected that the __Cl__~nr~ of metformin is comparable between two grou