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Pharmacokinetic studies of theophylline in dogs

โœ Scribed by B. C. McKIERNAN; C. A. NEFF-DAVIS; G. D. KORITZ; L. E. DAVIS; D. R. PHERIS


Book ID
114744154
Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
393 KB
Volume
4
Category
Article
ISSN
0140-7783

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The role of the kidneys in the elimination of theophylline was directly assessed using nephrectomized dogs. Data was analyzed by two different pharmacokinetic approaches. Analysis indicated that a given dosage regimen produced significantly different serum concentrations before and after nephrectomy