Pharmacokinetic parameters of oltipraz were compared after intravenous and oral administration at a dose of 30 mg/kg to control rats and rats with U-ARF. After intravenous administration to rats with U-ARF, the AUC was significantly greater (1100 versus 1730 mg ร min/mL) than that in control rats, a
Pharmacokinetic studies of propoxyphene IV: Effect of renal failure on systemic clearance in rats
โ Scribed by Stephen M. Roberts; Gerhard Levy
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 229 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3549
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To examine the mechanism accounting for the diverse alteration of hepatic metabolism of CYP3A substrates observed with renal function being severely impaired, the hepatic drug metabolizing activity was evaluated using liver microsomes prepared from rats with glycerol-induced acute renal failure (ARF