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Effects of acute renal failure on the pharmacokinetics of DA-7867, a new oxazolidinone, in rats

✍ Scribed by Soo K. Bae; Jong W. Kwon; Won B. Kim; Inchul Lee; Myung G. Lee

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
109 KB
Volume
27
Category
Article
ISSN
0142-2782

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## Abstract The changes in pharmacokinetics of DA‐8159 by omeprazole with respect to inhibition of CYP3A1/2 in rats were evaluated. After oral administration of DA‐8159 at dose of 30 mg/kg to rats pretreated with oral omeprazole at 30 mg/kg for 1 week, the total area under the plasma concentration–