Pharmacokinetic studies of cimetidine in patients with liver disease
β Scribed by Yamasaki, Hiroko ;Arima, Terukatsu ;Nagashima, Hideo
- Book ID
- 110679510
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 468 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0435-1339
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π SIMILAR VOLUMES
Following cimetidine administration, 60% of the dose is excreted as unchanged drug in the urine, and 40% is eliminated by metabolism. We evaluated the effect of liver disease on cimetidine disposition by comparing its kinetics in 7 healthy subjects and 8 patients with alcoholic cirrhosis. Cirrhotic
The pharmacokinetics of the dihydropyridine calcium antagonist isradipine has been examined in 8 healthy volunteers, 7 patients with non-cirrhotic chronic liver disease (CLD), and 8 patients with biopsy-proven cirrhosis (CIR). Isradipine was simultaneously given orally (12C 5 mg) and i.v. (13C 1 mg)