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Pharmacokinetic profile of glycyrrhizin in healthy volunteers by a new high-performance liquid chromatographic method

✍ Scribed by Yoshikazu Yamamura; Junichi Kawakami; Tomofumi Santa; Hajime Kotaki; Katsuyoshi Uchino; Yasufumi Sawada; Naomi Tanaka; Tatsuji Iga


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
517 KB
Volume
81
Category
Article
ISSN
0022-3549

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A high-performance liquid chromatographic method was developed to determine stobadin pharmacokinetics in dog and man. The relative bioavailability of stobadin dipalmitate compared with dihydrochloride was 46.4 per cent in dog. In man peak serum concentrations ranged from 12 to 289 ng ml-1 after a si