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Pharmacokinetic profile of conjugated verrucarol urinary metabolites in dogs

✍ Scribed by Shimon Barel; Boris Yagen; Meir Bialer

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
392 KB
Volume
15
Category
Article
ISSN
0142-2782

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✦ Synopsis

The pharmacokinetics and renal excretion of a trichothecene mycotoxin, verrucarol, were studied in six mongrel dogs following IV administration (0.4 mg kg-I).

The fraction of verrucarol excreted intact in the urine ranged from 0.9% to 2.7% of the administered dose. The fraction of verrucarol metabolites excreted in the urine was 32-609'0 for verrucaryl glucuronides and 32-47% for verrucaryl sulphates. These urinary conjugated metabolites were analysed quantitatively following their enzymatic hydrolysis. The half-life of verrucarol calculated from the urinary data of its conjugated metabolites was not significantly different from the half-life calculated from the plasma data of the parent compound.

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## Abstract The pharmacokinetics of cannabidiol (CBD) and six of its urinary metabolites was investigated in dogs. CBD was administered intravenously to three dogs, and urine was collected at specified time intervals over a period of 30h. The apparent terminal half‐life of CBD calculated from the s