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Pharmacokinetic modelling of the plasma concentration-time profile of the vitamin retinyl palmitate following intramuscular administration

✍ Scribed by D. Hartmann; D. Gysel; U. C. Dubach; I. Forgo

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 514 KB
Volume: 11
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510110805

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✦ Synopsis

Seven healthy male volunteers (2 1-24 y) received by the ventro-gluteal route a single dose of 100 000 I.U. of the vitamin retinyl palmitate (RP) in a water-miscible preparation (w) and 5 weeks later the same dose in an oily solution (S). After administration of W median (range) peak plasma concentrations of 5*6(44-8.7). lo3 pg 1--' were reached after 12 h and high levels persisted for another 50 h. At 144 h levels were still, by a factor 3, higher than baseline. Plasma levels of RP after S remained close to baseline (20-50 pg. 1-l) suggesting negligibly low bioavailability. The plasma level profile of R P after W could well be described by use of a one-compartment model with Weibulltype absorption and Michaelis-Menten elimination. The median (range) absolute bioavailability (estimates of lower limits) was 42 (32-52) per cent.

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