Pharmacokinetic Investigation of a 14C-Labelled β3/α Tetrapeptide in Rats
✍ Scribed by Hansjörg Wiegand; Bernard Wirz; Alain Schweitzer; Gerhard Gross; Maria I. Rodriguez Perez; Hendrik Andres; Thierry Kimmerlin; Magnus Rueping; Dieter Seebach
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 423 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1612-1872
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📜 SIMILAR VOLUMES
The stereoselective pharmacokinetics of two enantiomers of [14C]-labeled -(4-methylphenyl)-4-oxobutanonic acid] were investigated in rats. The blood levels of radioactivity after the oral administration of (+)-(S)-[14C]KE-298 were higher than that for (-)-(R)-[14C]KE-298; the AUC of the former was a
Syn thes is of 14C -labe 1 led 4 -chloro -3 -s u l f amoyl -N -(3aa, 4a, 5 , 6 7a,7aa-hexahydro-4,7-methano-isoindolin-Z-yl)-benzamide.
The synthesis in eight steps of the title compound from the commercially available[2O-"C]pregnenolone 1 is described. ## The expected I-[4-methyl-3-oxo-4-aza-5a-androstane-17~-[14C]carbonyl]-1,3-diisopropylurea ([14C]FCE 26073) was obtained with a radiochemical purity higher than 97% and a specif
## Abstract trans‐7,8‐Dihydrobenzo[a]pyrene‐7,8‐diol‐7‐^14^C (VI) and (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]‐pyrene‐7‐^14^C (VII) were prepared at a specific activity of 53.9 mCi/mmole by a multi‐step synthetic sequence using K^14^CN as the labeled precursor. The overall radio