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Pharmacokinetic interactions of alcohol and acetylsalicylic acid

✍ Scribed by O. Melander; A. Lidén; A. Melander

Book ID
104658215
Publisher
Springer
Year
1995
Tongue
English
Weight
305 KB
Volume
48
Category
Article
ISSN
0031-6970

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✦ Synopsis

This study assessed the influence of acetylsalicylic acid (ASA, 1.0 g), ibuprofen (0.8 g) and paracetamol (1.0 g) on the single-dose kinetics of ethanol in 12 healthy volunteers ingesting the drug and a standardised 1840-kJ breakfast 1 h before intake of ethanol. It also assessed the influence of ethanol on the single-dose kinetics of 1.0 g ASA in ten fasting healthy volunteers. Plasma concentrations of ethanol were measured by gas chromatography, and those of the drugs by liquid chromatography. There was no effect of ASA, ibuprofen or paracetamol on the single-dose kinetics of ethanol, but concurrent intake of ethanol reduced the peak concentration of ASA by 25%.

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Pharmacokinetics of acetylsalicylic acid
Pharmacokinetics of acetylsalicylic acid and salicylic acid after intravenous administration in man
✍ Malcolm Rowland; Sidney Riegelman 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 English ⚖ 568 KB

The pharmacokinetics of acetylsalicylic acid (ASA, 650 mg.) and salicylic acid (SAY 500 mg.) were studied following intravenous administration in males. The resultant plasma concentration-time curves were described by bi-exponential equations. The half-life of the first exponent was 2-5 min. for bot