Pharmacokinetic interaction between valproic acid and meropenem
✍ Scribed by Didier Clause; Pierre-Yves Decleire; Roger Vanbinst; Aurélie Soyer; Philippe Hantson
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 112 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1432-1238
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📜 SIMILAR VOLUMES
Carbapenem antibiotics cause pharmacokinetic interaction with valproic acid (VPA) in clinical pharmacotherapy. Here, we investigated the mechanism of interaction from the viewpoint of erythrocyte distribution of VPA in rats and humans. Imipenem or panipenem was administered intravenously and then VP
The effects of three levels of salicylic acid on the steady-state plasma concentrations of free and total valproic acid were examined in catheterized rhesus monkeys. Valproate was infused intravenously for a total of 41 hr, and salicylate was added after the first 8 hr. The three salicylate infusion