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Pharmacokinetic interaction between diltiazem and nortriptyline

✍ Scribed by S. Krähenbühl; V. Smith-Gamble; C. L. Hoppel

Publisher
Springer
Year
1996
Tongue
English
Weight
199 KB
Volume
49
Category
Article
ISSN
0031-6970

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✦ Synopsis

Objective:

Case report of a pharmacokinetic interaction between diltiazem and nortriptyline.

Methods:

Determination of plasma nortriptyline concentrations by hplc. calculation of nortriptyline clearances and half-life by formulae used routinely in therapeutic drug monitoring.

Results:

The average plasma concentration of nortriptyline at steady state (css) divided by the amount of nortriptyline administered per time rose significantly in a patient with concomitant administration of diltiazem, suggesting increased bioavailability and/or decreased clearance of nortriptyline.

Conclusions:

There is a significant pharmacokinetic interaction between diltiazem and nortriptyline, which is probably due to a reduction in the first pass clearance of nortriptyline, leading to an increase in its bioavailability.

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