Previous reports have indicated that administration of the calcium antagonist diltiazem results in major changes in the pharmacokinetics of cyclosporin A (CyA). A new clinical trial was undertaken in 22 renal transplant patients receiving a constant dose of cyclosporin to further explore this intera
Digoxin-diltiazem interaction: A pharmacokinetic evaluation
β Scribed by W. N. Jones; K. B. Kern; J. P. Rindone; M. Mayersohn; M. Bliss; S. Goldman
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 373 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0031-6970
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## Objective: Case report of a pharmacokinetic interaction between diltiazem and nortriptyline. ## Methods: Determination of plasma nortriptyline concentrations by hplc. calculation of nortriptyline clearances and half-life by formulae used routinely in therapeutic drug monitoring. ## Results:
The pharmacokinetic interaction between diltiazem and amiodarone was investigated in dogs. In the presence of amiodarone, diltiazem's AUC values were sigmfkantly increased and its total body clearance and volume of distribution at steady-state significantly decreased. This study indicates that cardi