Pharmacokinetic factors in sex differences in Δ9-tetrahydrocannabinol-induced behavioral effects in rats
✍ Scribed by Alan H. Tseng; Joseph W. Harding; Rebecca M. Craft
- Book ID
- 116283593
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 122 KB
- Volume
- 154
- Category
- Article
- ISSN
- 0166-4328
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In an attempt to identify the possible role of brain biogenic amines and adrenocorticotrophic hormone (ACTH) release in the behavioral and physiological effects of A 9-tetrahydrocannabinol (THC), the time course of drug action was studied. THC (20 mg/kg) was administered daily for 1, 4, 21, or 42 da
Rats treated chronically with A 9-tetrahydrocannabinol (THC, daily oral dose 20 mg/kg) were examined for residual effects on a variety of behaviors following a 1-4month drug-free period. Learning a 12-arm radial maze and a differential reinforcement of low-rate responding (DRL-20) task was significa