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Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats

✍ Scribed by Kumar, K. Kishore; Priyanka, Leena; Gnananath, K.; Babu, P. Ravindra; Sujatha, S.


Book ID
123612488
Publisher
Springer-Verlag
Year
2014
Tongue
English
Weight
425 KB
Volume
40
Category
Article
ISSN
0378-7966

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Digoxin and beta-methyldigoxin were evaluated pharmacokinetically in terms of P-glycoprotein (P-gp)-mediated drug interactions in rats. Evaluation was made by measuring the effects of a potent P-gp inhibitor (verapamil, cyclosporin A) on in vitro efflux transport of these compounds across the everte