## Abstract A steadyβstate model is presented of the metabolism of imipramine. In this model, the __N__βdemethylation and 2βhydroxylation rates of imipramine were measured with and without the presence of metabolites by using a tritium isotope of imipramine. At an imipramine concentration of 5βΞΌmol
β¦ LIBER β¦
Pharmacokinetic correlation between in vitro hepatic microsomal enzyme kinetics and in vivo metabolism of imipramine and desipramine in rats
β Scribed by Masato Chiba; Shoichi Fujita; Tokuji Suzuki
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 785 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0022-3549
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