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Pharmacokinetic aspects of the sublingual administration of vincamine

✍ Scribed by J-M. Aiache; M-C. Delatte; P-P. Leblanc; J-P. Kantelip; J-L. Steimer

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 713 KB
Volume: 11
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510110402

No coin nor oath required. For personal study only.

✦ Synopsis

The sublingual absorption of vincamine used as tracer occurs in two successive absorption steps: true sublingual absorption and absorption in the gastrointestinal tract of the drug dissolved in the saliva and not absorbed through the buccal mucosa. This is confirmed by a pharmacokinetic study and simulation. These two successive absorptions can explain the increase in the amounts of drug absorbed.

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