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Pharmacokinetic and Pharmacoimmunodynamic Interactions Between Prednisolone and Sirolimus in Adrenalectomized Rats

✍ Scribed by Geraldine M. Ferron; Nancy A. Pyszczynski; William J. Jusko

Book ID
110397728
Publisher
Springer
Year
1999
Tongue
English
Weight
994 KB
Volume
27
Category
Article
ISSN
1573-8744

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The interactions of four HIV-protease inhibitors, ritonavir (RIT), saquinavir (SAQ), indinavir (IND) and nelfinavir (NEL), were examined by in vitro metabolic studies using rat liver microsomal fractions. The substrate concentrations employed were 0.75 12 mM, and the inhibitor concentrations were 2.