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Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients

✍ Scribed by Rouits, E; Charasson, V; Pétain, A; Boisdron-Celle, M; Delord, J-P; Fonck, M; Laurand, A; Poirier, A-L; Morel, A; Chatelut, E

Book ID
109999768
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
149 KB
Volume
99
Category
Article
ISSN
0007-0920

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Cost effectiveness of pharmacogenetic te
Cost effectiveness of pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 before irinotecan administration for metastatic colorectal cancer
✍ Heather Taffet Gold; Michael J. Hall; Victoria Blinder; Bruce R. Schackman 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB

## Abstract ## BACKGROUND: The objective of this study was to examine the cost effectiveness of using a pharmacogenetic test for uridine diphosphate glycosyltransferase 1A1\*28 (UGT1A1\*28) variant homozygosity before administering irinotecan to patients with metastatic colorectal cancer. ## METH