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Pharmacokinetic and pharmacodynamic studies of the effect of ketoconazole on reproductive function in male rats

✍ Scribed by J. M. WANG; X. L. WU; W. YOU; L. X. LING; J. WU; G. Y. ZHANG


Book ID
114730467
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
527 KB
Volume
15
Category
Article
ISSN
0105-6263

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To evaluate methodology for in vivo interaction studies of benzodiazepines (BZs) and ketoconazole (KCZ) in animal models, this study assessed the pharmacokinetics and electroencephalographic (EEG) effect of KCZ, and suitable dosage regimens of KCZ to maintain sufficiently high KCZ concentrations to