Quantification of metoprolol Beta2-adren
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M.C.P. Braat; R.E. Jonkers; C.J. van Boxtel
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Article
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1992
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Elsevier
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English
โ 668 KB
An integrated pharmacokinetic-pharmacodynamic model was used to quantify the beta 2-blocking activity of metoprolol in seven asthmatic patients. The patients received a subcutaneous dose of terbutaline on two consecutive days. On day 1 they were pretreated with placebo and on day 2 with metoprolol 1