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Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after multiple subcutaneous doses in healthy subjects

✍ Scribed by Wojciech Krzyzanski; William J. Jusko; Mary C. Wacholtz; Neil Minton; Wing K. Cheung


Book ID
113591537
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
392 KB
Volume
26
Category
Article
ISSN
0928-0987

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The pharmacokinetics of recombinant human Epo (rHuEpo) were investigated after subcutaneous administration to horses. Four horses received a single 30 IU kg-' dose of rHuEpo. One horse received three repeated doses of 120 IU kg-' at 48 h intervals. Plasma erythropoietin (Epo) was measured by radioim