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Pharmacodynamics of the antiarrhythmic disopyramide in healthy humans: Correlation of the kinetics of the drug and its effects

✍ Scribed by Peter H. Hinderling; Edward R. Garrett

Book ID
112474226
Publisher
Springer
Year
1976
Tongue
English
Weight
645 KB
Volume
4
Category
Article
ISSN
1573-8744

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During steady-state treatment with disopyramide, its main and active metabolite, mono-N-dealkylated disopyramide, was reported to reach concentrations that were equal to or higher than the parent drug in 25% of 70 evaluated patients. This metabolite has been found to have a more pronounced anticholi