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Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1

✍ Scribed by D. J. HARRINGTON; R. GORSKA; R. WHEELER; S. DAVIDSON; S. MURDEN; C. MORSE; M. J. SHEARER; A. D. MUMFORD


Book ID
109152675
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
223 KB
Volume
6
Category
Article
ISSN
1538-7933

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## Abstract The TREK1 gene has been linked to a depression‐resistant phenotype in rodents and antidepressant response in humans, but the neural mechanisms underlying these links are unclear. Because TREK1 is expressed in reward‐related basal ganglia regions, it has been hypothesized that TREK1 gene