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Pharmacodynamic Model of Parathyroid Hormone Modulation by a Negative Allosteric Modulator of the Calcium-Sensing Receptor

✍ Scribed by Anson K. Abraham; Tristan S. Maurer; Amit S. Kalgutkar; Xiang Gao; Mei Li; David R. Healy; Donna N. Petersen; David A. Griffith; Donald E. Mager


Book ID
111767717
Publisher
American Association of Pharmaceutical Scientists
Year
2011
Tongue
English
Weight
231 KB
Volume
13
Category
Article
ISSN
1550-7416

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The discovery of a series of novel and orally efficacious type II calcimimetics, developed from the lead compound 1, is described herein. Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model.