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Discovery of a class of calcium sensing receptor positive allosteric modulators; 1-(benzothiazol-2-yl)-1-phenylethanols

✍ Scribed by Magnus Gustafsson; Jacob Jensen; Sine M. Bertozzi; Erika A. Currier; Jian-Nong Ma; Ethan S. Burstein; Roger Olsson


Book ID
104004678
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
620 KB
Volume
20
Category
Article
ISSN
0960-894X

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✍ Paul E. Harrington; David J. St. Jean Jr.; Jeffrey Clarine; Thomas S. Coulter; M πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 639 KB

The discovery of a series of novel and orally efficacious type II calcimimetics, developed from the lead compound 1, is described herein. Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model.