β Scribed by Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm
No coin nor oath required. For personal study only.
This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fifth Edition completely updates the previous edition, and also includes additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech and enzyme replacement therapy.
Front Matter ....Pages i-xxiii
Molecular Biotechnology: From DNA Sequence to Therapeutic Protein (Ronald S. Oosting)....Pages 1-18
Biophysical and Biochemical Characteristics of Therapeutic Proteins (Wim Jiskoot, Daan J. A. Crommelin)....Pages 19-32
Protein Stability and Characterization (Atanas Koulov)....Pages 33-56
Production and Purification of Recombinant Proteins (Alfred Luitjens, Emile van Corven)....Pages 57-82
Formulation of Biologics Including Biopharmaceutical Considerations (Daan J. A. Crommelin, Andrea Hawe, Wim Jiskoot)....Pages 83-103
Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides and Proteins (Bernd Meibohm)....Pages 105-137
Immunogenicity of Therapeutic Proteins (Wim Jiskoot, Theo Rispens, Grzegorz Kijanka)....Pages 139-150
Monoclonal Antibodies: From Structure to Therapeutic Application (Rong Deng, C. Andrew Boswell, Wendy S. Putnam, Meina T. Tang, Amit Garg, Chunze Li et al.)....Pages 151-190
Genomics, Other βOMICβ Technologies, Precision Medicine, and Additional Biotechnology-Related Techniques (Robert D. Sindelar)....Pages 191-237
Dispensing Biotechnology Products: Handling, Professional Education, and Product Information (Robert D. Sindelar)....Pages 239-251
Economic Considerations in Medical Biotechnology (Amit S. Patel, Kartick P. Shirur)....Pages 253-263
Regulatory Framework for Biosimilars (Vinod P. Shah, Daan J. A. Crommelin)....Pages 265-274
An Evidence-Based Practice Approach to Evaluating Biotechnologically Derived Medications (James P. McCormack)....Pages 275-280
Vaccines (Wim Jiskoot, Gideon F. A. Kersten, Enrico Mastrobattista, Bram SlΓΌtter)....Pages 281-304
Oligonucleotides (Raymond M. Schiffelers, Erik Oude Blenke, Enrico Mastrobattista)....Pages 305-322
Gene Therapy (Hao Wu, Amit Kumar Chaudhary, Ram I. Mahato)....Pages 323-355
Advanced Therapies: Clinical, Non-clinical and Quality Considerations (Karin H. Hoogendoorn)....Pages 357-402
Insulin (John M. Beals, Michael R. DeFelippis, Chad D. Paavola, David P. Allen, Ashish Garg, D. Bruce Baldwin)....Pages 403-427
Follicle-Stimulating Hormone (Tom Sam, Renato de Leeuw)....Pages 429-435
Human Growth Hormone (Le N. Dao, Barbara Lippe, Michael Laird, Ingrid Beierle)....Pages 437-449
Recombinant Coagulation Factors and Thrombolytic Agents (Koen Mertens, Alexander B. Meijer)....Pages 451-470
Recombinant Human Deoxyribonuclease I (Robert A. Lazarus, Jeffrey S. Wagenerβ )....Pages 471-488
Monoclonal Antibodies in Cancer (JΓΌrgen Barth)....Pages 489-519
Hematopoietic Growth Factors (Juan Jose PΓ©rez-Ruixo)....Pages 521-535
Monoclonal Antibodies in Solid Organ Transplantation (Nicole A. Pilch, Holly B. Meadows, Rita R. Alloway)....Pages 537-555
Antibody-Based Biotherapeutics in Inflammatory Diseases (Honghui Zhou, Yan Xu, Amarnath Sharma)....Pages 557-617
Interferons and Interleukins (Jean-Charles Ryff, Sidney Pestka)....Pages 619-643
Back Matter ....Pages 645-653
Biomedicine; Pharmaceutical Sciences/Technology; Biomedical Engineering/Biotechnology
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<p>This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the
This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pha
This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pha
Completely revised text that reflects to emergent trends and cutting-edge advances in pharmaceutical biotechnology, this Third Edition provides a well-balanced framework for understanding every major aspect of pharmaceutical biotechnology, including drug development, production, dosage forms, admini