## Abstract ## BACKGROUND Up to 5% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia (Ph) translocation t(9;22)(q34;q11) or a __bcr__/__abl__ molecular rearrangement. Although the diagnostic criteria of this entity are still under debate, there is general agreement t
Ph-negative and bcr-negative atypical chronic myelogenous leukemia: biological features and clinical outcome
β Scribed by E. Montefusco; G. Alimena; F. Lo Coco; M. R. De Cuia; Y. -Z. Wang; M. A. Aloe Spiriti; F. Mancini; M. Cedrone; M. Mancini; F. Mandelli
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 764 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0939-5555
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A 23-year-old man developed Ph'-positive chronic myelogenous leukemia in 1966. After two short courses of busulfan not associated with severe myelosuppression, the frequency of Ph'-positive metaphases in his bone marrow was 40%. Over the next eight years, he remained hematologically stable without f