## Abstract The effect of pH~o~ on plasma membrane chloride current of cultured rat cortical astrocytes was investigated using the wholeโcell patchโclamp technique. In the presence of intraโ and extracellular solutions with symmetrical high Cl^โ^ content and K^+^ channel inhibitors, the cells exhib
pH modulation of an inward rectifier chloride current in cultured rat cortical astrocytes
โ Scribed by S. Ferroni; M. Nobile; M. Caprini; C. Rapisarda
- Book ID
- 117489784
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 337 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0306-4522
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๐ SIMILAR VOLUMES
The biophysical and pharmacological properties of the inwardly rectifying Cl ฯช conductance (I Clh ), expressed in rat type-1 neocortical cultured astrocytes upon a long-term treatment (1-3 weeks) with dibutyryl-cyclic-AMP (dBcAMP), were investigated with the whole-cell patch-clamp technique. Using i
## Abstract A pathophysiological increase in free arachidonic acid (AA) is thought to regulate the channelโmediated astrocytic swelling occurring in several brain injuries. We report that in cultured rat typeโ1 cortical astrocytes, exposure to 10 ฮผM AA activates an open rectifier K^+^ channel, whic