Identification of an inward rectifier potassium channel gene expressed in mouse cortical astrocytes
β Scribed by Luyi Li; Valerie Head; Leslie C. Timpe
- Book ID
- 102677945
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 895 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0894-1491
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A pathophysiological increase in free arachidonic acid (AA) is thought to regulate the channelβmediated astrocytic swelling occurring in several brain injuries. We report that in cultured rat typeβ1 cortical astrocytes, exposure to 10 ΞΌM AA activates an open rectifier K^+^ channel, whic
Astrocytes are an abundant glial cell type of the central nervous system that appear to play a role in regulating extracellular potassium concentrations in brain, thereby contributing to the maintenance of normal neuronal activity. Voltage-gated potassium conductances, shown to be present in astrocy
## Abstract Glial cellβmediated potassium and glutamate homeostases play important roles in the regulation of neuronal excitability. Diminished potassium and glutamate buffering capabilities of astrocytes result in hyperexcitability of neurons and abnormal synaptic transmission. The role of the dif