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pH mapping in living tissues: An application of in vivo31P NMR chemical shift imaging

✍ Scribed by Shigehiro Morikawa; Toshiro Inubushi; Kohichi Kito; Chie Kido

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
408 KB
Volume
29
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Chemical shifts were extracted from in vivo^3^‐dimensional^31^P NMR CIS data and pH images were constructed. The images could spatilly resolve tissue pH ranging from 5.8 to 7.2 (with uncertainty of 0.11‐0.17 pH unit)in an ischemia‐reperfusion model of diabetic rat calf muscles.

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## Abstract Localized ^31^P NMR spectroscopy was used to evaluate the spatial heterogeneity of the metabolic response of RIF‐1 tumors to hydralazine. Volume localized ^31^P spectra were obtained from subcutaneous RIF‐1 tumors using one‐dimensional chemical‐shift imaging, before and 20 min after tre