Spatial heterogeneity of the metabolic response of RIF-1 tumors to a vasoactive agent evaluated in vivo by one-dimensional 31P chemical-shift imaging
✍ Scribed by Z. M. Bhujwalla; S. J. Blackband; J. P. Wehrle; J. D. Glickson
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 285 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Localized ^31^P NMR spectroscopy was used to evaluate the spatial heterogeneity of the metabolic response of RIF‐1 tumors to hydralazine. Volume localized ^31^P spectra were obtained from subcutaneous RIF‐1 tumors using one‐dimensional chemical‐shift imaging, before and 20 min after treatment with 5 mg/kg hydralazine, administered intravenously. Following treatment all of the tumors showed an overall decrease in the ratio of nucleoside triphosphate (NTP) to inorganic phosphate (P~i~) and a decrease in pH. However, spatial localization revealed that the reduction in NTP/P~i~ was not uniform within some tumors. This was partly due to regional differences in the levels of metabolites existing before treatment. Normal tissue adjacent to the tumor did not show a significant decrease in high‐energy metabolites or pH.