𝔖 Bobbio Scriptorium
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pH indicator titration: A novel fast pKa determination method

✍ Scribed by Xiaole Kong; Tao Zhou; Zudong Liu; Robert C. Hider

Book ID
102398165
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
168 KB
Volume
96
Category
Article
ISSN
0022-3549

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✦ Synopsis

This study describes a fast spectrophotometic titration method for apparent ionization constant (pKa) determination. In this method, a Universal pH indicator is utilized instead of the conventional pH electrode. An autoburette is set to add HCl at a constant rate to a vigorously stirred 1 cm UV cuvette which contains sample and indicator solution. A spectrophotometer continuously records the spectra. Acquired spectral data are processed by calculating the pH from the indicator spectra in the visible region and extracting sample spectra from the UV region. Five compounds possessing pKa values in the range 2-10 were investigated. These results differed from measurements by conventional spectrophotometric titration by AE0.05 to AE0.10 log unit.

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