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pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers

✍ Scribed by Sibylle Neuhoff; Anna-Lena Ungell; Ismael Zamora; Per Artursson


Book ID
113591474
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
345 KB
Volume
25
Category
Article
ISSN
0928-0987

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The objective of this study was to investigate the mechanisms by which berberine is transported in the secretory and absorptive directions across Caco-2 cell monolayers. The basolateral-to-apical (B-A) flux was 30-fold greater than the apical-to-basolateral flux and temperature dependent (i.e., dras