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pH dependent conformation of physalaemin

✍ Scribed by HÖLZEMANN, G. ;PACHLER, K.G.R.

Book ID
115098982
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
633 KB
Volume
34
Category
Article
ISSN
0367-8377

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Two new cyclic analogues of physalaemin were designed on the basis of the conformation found in DMSO solution. Glp-Ala-cyclo ( -Asp-Pro-Asn-Lys-) -Phe-Tyr-Gly-Leu-Met-NH2 ( 1 ) was synthesized by cyclization of physalaemin. In 2 the Asp residue was replaced by Glu. The linear analogue of 2 was synt