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PGN 1091, a novel 5-HT2B receptor antagnist for the treatment of irritable bowel syndrome

โœ Scribed by Borman, Richard; Oxford, Alec; Denny, Sarah; Sykes, Andrew; Samra, Satinder; Woodrooffe, Amanda; Eagle, mark; Coleman, Robert; Clark, Ken


Book ID
122896964
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
258 KB
Volume
124
Category
Article
ISSN
0016-5085

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โœ David D. Manning; Christopher L. Cioffi; Alexander Usyatinsky; Kevin Fitzpatrick ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 474 KB

Serotonin type 3 (5-HT(3)) receptor partial agonists are being targeted as potential new drugs for the treatment of irritable bowel syndrome (IBS). Two new chemical series bearing indazole and indole cores have exhibited nanomolar binding affinity for the h5-HT(3)A receptor. A range of partial agoni