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PGE2 and LTB4 inhibit cytokine-stimulated nitric oxide synthase type 2 expression in isolated rat hepatocytes

✍ Scribed by B.G. Harbrecht; Y.M. Kim; E.M. Wirant; R.A. Shapiro; T.R. Billiar

Book ID: 113215285
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 974 KB
Volume: 52
Category: Article
ISSN: 0090-6980
DOI: 10.1016/0090-6980(96)00056-1

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## Abstract Since NO production by NOS‐2 made by astrocytes activated by proinflammatory cytokines contributes to the killing of neurons in variously damaged human brains, knowing the mechanisms responsible for NOS‐2 expression should contribute to developing effective therapeutics. The expression