PET Brain Imaging of Neuropeptide Y2 Receptors Using N-11C-Methyl-JNJ-31020028 in Pigs
โ Scribed by Winterdahl, M.; Audrain, H.; Landau, A. M.; Smith, D. F.; Bonaventure, P.; Shoblock, J. R.; Carruthers, N.; Swanson, D.; Bender, D.
- Book ID
- 127161676
- Publisher
- The Society of Nuclear Medicine
- Year
- 2014
- Tongue
- English
- Weight
- 757 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0161-5505
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## N1-(111C]-Methyl>2-Br-LSD ([llC] -MBL) has been developed as a positron emission tomography (PET) imaging agent for serotonin 5-HT2 receptors. In vitro receptor binding assays with nonradioactive MBL show high-affinity binding to serotonin 5-HT2 receptors (Ki = 0.5 nM), a secondary interaction
## Abstract A convenient synthesis of [Nโmethylโ^11^C]โ3โ[(6โdimethylamino)pyridinโ3โyl]โ2,5โdimethylโ__N__,__N__โdipropylpyrazolo[1,5โa]pyrimidineโ7โamine (R121920), a highly selective CRF~1~ antagonist has been developed as a potential PET ligand. 3 โ [(6 โ methylamino)pyridin โ 3 โ yl]โ2,5โdimet