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Pet and spect radiotracers for imaging muscarinic cholinergic receptors: Radiosyntheses of dexetimide and analogues with 11C, 18F, and 123I

✍ Scribed by Wilson, A.A; Dannals, R.F; Ravert, H.T; Scheffel, U; Frost, J.J; Mueller-Gaertner, H; Wagner, H.N


Book ID
123105133
Publisher
Elsevier Science
Year
1992
Weight
85 KB
Volume
19
Category
Article
ISSN
0883-2897

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Synthesis of radiotracers for studying m
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Dexetimide (Fig. la), a potent muscarinic cholinergic receptor antagonist, and levetimide (Fig. lb), its pharmacologically inactive enantiomer, were labeled with "C for non-invasive in vivo studies of muscarinic cholinergic receptors in the human brain using positron emission tomography. The synthes