PET analysis of human dopamine receptor subtypes using11C-SCH 23390 and11C-raclopride
β Scribed by L. Farde; C. Halldin; S. Stone-Elander; G. Sedvall
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 710 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0033-3158
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π SIMILAR VOLUMES
The optimal conditions for the synthesis of 11C-labelled SCH 23390 by radio-methylation of its desmethyl precursor, SCH 24518, with [11C]iodomethane are described. Isocratic reversed phase HPLC was used for the purification of [11C]SCH 23390. The specific activity range in 30 runs was 10-235 Ci/mmol
The "C-labelled radioligands raclopride, SCH 23390 and N-methyl-spiroperidol are well established for examination of central dopamine receptors by positron emission tomography (PET). Thin layer chromatography was used to examine the composition of radioactivity in plasma after intravenous injection
A new synthesis is described for the production of the positron emitting radiopharmaceutical R-(+)-7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-N-[11C]methyl-1-phenyl-1H- 3-benzazepine (SCH 23390, 2a). This novel method involves reductive carboxylation, in which [11C]CO2 is reacted with the trimethylsily