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Pesticides and the induction of aneuploidy in human sperm

✍ Scribed by Härkönen, K.


Book ID
119984561
Publisher
S. Karger AG
Year
2005
Tongue
French
Weight
166 KB
Volume
111
Category
Article
ISSN
1424-8581

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## I The frequency and distribution of aneuploidy was compared in 11,615 karyotyped human sperm and 772 karyotyped human oocytes to determine if all chromosomes are equally likely to be involved in aneuploid events or if some chromosomes are particularly susceptible to nondisjunction. The frequenc

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Rapid and specific identification of chromosomes can be attained in situ using the PRimed IN Situ (PRINS) labelling technique. We have adapted this technique to mature human sperm in combination with a protocol for simultaneous decondensation and denaturation of sperm nuclei. This strategy allowed u