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Perturbation of RET signaling in the embryonic kidney

โœ Scribed by Ehrenfels, Christian W. ;Carmillo, Paul J. ;Orozco, Olivia ;Cate, Richard L. ;Sanicola, Michele

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
633 KB
Volume
24
Category
Article
ISSN
0192-253X

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โœฆ Synopsis

We have used a RET-Ig fusion protein to disrupt signaling in the rat embryonic kidney development pathway. Treatment of embryonic kidney organ cultures with RET-Ig results in a decrease in branching of the ureteric bud and a down regulation in expression of the Wnt-11, Wnt-4, and ld genes. These data suggest that Wnt-11, Wnt-4, and ld function downstream of RET signaling in normal development. Expression of BMP-7, shh, and ptc were uneffected by RET-Ig treatment, implying that these genes are regulated independently of ret. We have also performed immunohistochemistry with a GFRโฃ-1 specific polyclonal antisera to localize GFRโฃ-1 protein expression in the developing kidney. Dev. Genet.

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