Perspectives on the use of microspectrophotometry in the diagnosis of pretumorous processes and malignant tumors

✍ Scribed by G. G. Avtandilov

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 333 KB
• Volume: 38
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197607)38:1<254::aid-cncr2820380138>3.0.co;2-o

✦ Synopsis

Comparative microspectrophotometric study of the nuclear Feulgen DNA content in pretumorous processes a n d cancers (larynx, endometrium, large intestine, and stomach) has made it possible to formulate a n exponential law of DNA accumulation in cell populations in proliferating and malignant tissue. T h e dynamics of changes in the "index of DNA accumulation" can be used as a n objective quantitative diagnostic test. A scale of malignant transformation was proposed, with which the degree of probability of malignancy in pretumorous processes could be estimated. T h e data obtained allowed the author to propose a hypothesis of DNA superproduction as the basic cause of progressive neoplastic growth.