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Perspectives on the Discovery of Small-Molecule Modulators for Epigenetic Processes

✍ Scribed by Lu, Quinn ;Quinn, Amy M. ;Patel, Mehul P. ;Semus, Simon F. ;Graves, Alan P. ;Bandyopadhyay, Deepak ;Pope, Andrew J. ;Thrall, Sara H.


Book ID
111680473
Publisher
SAGE Publications
Year
2012
Tongue
English
Weight
729 KB
Volume
17
Category
Article
ISSN
2472-5552

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## Abstract PTP1B is a protein tyrosine phosphatase involved in insulin and leptin signaling and is a primary mechanism for down‐regulating both the insulin and leptin receptor signaling pathways. Animals deficient in PTP1B have improved glucose regulation and lipid profiles and are resistant to we