## Abstract Equations for calculation of constants of enzyme activation and nontrivial types of enzyme inhibition, which are not reported in the literature, have been deduced. Examples of using these equations are also presented. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 24:145–154, 2010
Perspectives of data analysis of enzyme inhibition and activation, Part 1: Use of the three-dimensional Km′ V′I coordinate system for data analysis of enzyme inhibition and activation
✍ Scribed by Vladimir I. Krupyanko
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 111 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1095-6670
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The possibility of construction of the three‐dimensional (unfolded and folded) K~m~′ V′I rectangular coordinate systems convenient for vector representation of inhibited and activated enzymatic reactions as well as of a two‐dimensional K~m~′ V′ scalar rectangular coordinate system convenient for diagrammatic representation of enzymatic reactions is considered. The perspectives of using the properties of the three‐dimensional L vectors and their scalar L projections for data analysis of enzyme inhibition and activation are analyzed. © 2009 Wiley Periodicals, Inc. J Biochem Mol Toxicol 23:97–100, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20273
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## Abstract A parametrical classification of types of enzymatic reactions that counts 15 types—7 inhibited reactions, 7 activated ones, and 1 type of initial (uninhibited and nonactivated) reaction—is considered. The system permits taking into account the number of parameters of enzymatic reactions
## Abstract Equations for calculation of the initial rates of activated enzymatic reactions and the inhibited enzymatic reactions, unavailable in experimental enzymology, were obtained. Examples of practically using of these equations are given. © 2009 Wiley Periodicals, Inc. J Biochem Mol Toxicol