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Personality traits and theophylline metabolism

✍ Scribed by Abraham G. Hartzema; Sal Pancorbo; Scott Davis

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 273 KB
Volume: 3
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510030404

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The objectives of this study were to investigate the relationship between personality trait variables and theophylline disposition in asthmatic patients.

Twenty‐five patients admitted to a hospital who required intravenous theophylline for bronchodilation were studied. Data on theophylline half‐life, and the patients' histories on congestive heart failure, liver disease, and smoking behaviour were abstracted. Eysenck's personality inventory was administered to obtain a score on the two personality traits: neuroticism and extroversy.

High neurotic patients showed a significantly (p< 0.005) lower theophylline half‐life. Neuroticism appeared to be, in this patient population, a more important determinant of theophylline half‐life than variables such as congestive heart failure, liver disease, or smoking behaviour.

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