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Persistent interferon transgene expression by RNA interference-mediated silencing of interferon receptors

✍ Scribed by Yuki Takahashi; Elin Vikman; Makiya Nishikawa; Mitsuru Ando; Yoshihiko Watanabe; Yoshinobu Takakura


Book ID
118284380
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
236 KB
Volume
12
Category
Article
ISSN
1099-498X

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## Abstract RNA interference (RNAi) is a potent mechanism for local silencing of gene expression and can be used to study loss‐of‐function phenotypes in mammalian cells. We used RNAi to knockdown specifically the expression of choline acetyltransferase (ChAT), the enzyme of acetylcholine biosynthes